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Therefore, it is possible that fructose-induced FGF21 may have other possible targets such as the mTORC1-NRF2 signaling pathway to protect against APAP-induced hepatotoxicity

Next, to scrutinize the effects of both CHAC1 and Fe-S cluster synthesis on mitochondrial cysteine availability under limiting conditions, we assessed matrix cysteine in CHAC1 and/or NFS1-deficient H2009-HA-Mito cells subject to a 2 h starvation period (Fig

Disclosures: Kristina Folta: Nothing to Disclose, John Mendelson: Ria Health: Founder and CMO, Judith Prochaska: Achieve Life Sciences: Consultant, Oneleaf Health: Advisor, Kevin Hallgren: Nothing to Disclose, Weiyu Wu: Nothing to Disclose, Allison Kwong: Nothing to Disclose 1488 CIRRHOSIS IS ASSOCIATED WITH WORSE OUTCOMES IN HOSPITALIZATIONS FOR ALCOHOL WITHDRAWAL Yasmin Ali 1 Spencer Goble 1 , 1 Hennepin Healthcare Background: Alcohol cessation is critical to the prevention of further liver dysfunction and decompensation in patients with cirrhosis