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Proc Natl Acad Sci U S A (2006) 103(20):763742.10.1073/pnas.0601638103 132 SasakiAYasukawaHSuzukiAKamizonoSSyodaTKinjyoIet alCytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

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Identifying ways to activate adiponectin/AdipoR signaling is expected to pave the way for the development of definitive therapies for the metabolic syndrome, type 2 diabetes, and atherosclerosis