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doi: 10.1016/j.foodres.2022.111338 2

Consistent with inefficient conversion of pyruvate to acetyl-CoA, there was a clear trend for elevated m+3 lactic acid in the liver of Cse / mice (Extended Data Fig

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Furthermore, a functional lactic acid/HIF/2- c-myc signalling pathway has been identified in tumor cells, and lactic acid in the in vitro environment not only was able to stabilize HIF-2 but also activated c-myc [121]