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The glucagon-like peptide-1 analogue liraglutide reduces seizures susceptibility, cognition dysfunction and neuronal apoptosis in a mouse model of Dravet syndrome

Different drug compounds are thought to have different modes in DILI pathogenesis, including prompting mitochondrial dysfunction, as part of the characteristic feature of oxidative stress driven toxicity [34, 68]

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MOTS-c plays a role in this energy regulation, often acting as a signaling molecule between the mitochondria and the rest of the cell

The primary endogenous enzymatic source of O 2 and H 2 O 2 are through the electron transport chain (ETC) in mitochondria and transmembrane NADPH oxidases (NOXs) ( Figure 1 In SLE, ROS play an important role in cellular signaling and are considered hazardous reactive particles to the cells because they damage the intracellular proteins, lipids, and nucleic acids, producing toxic base pairs, leading to DNA damage

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