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EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision

Antigen-presenting cells (APCs) of the innate immune system, necessary for adaptive immune activation, have a decreased peripheral presence and impaired activity due to alcohol (97, 98)

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If standardized peptide formulations can be verified and administered within controlled protocols, these agents may represent a future adjunct to evidence-based perioperative care, particularly in populations undergoing TJA where wound healing, metabolic health, and inflammatory regulation strongly influence outcomes

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