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, & Ohigashi, H

(38) noted that the activation of nuclear receptor subfamily 1 group D member 1 (NR1D1), which participates in inflammation, lowered the expression of pro-inflammatory cytokines and matrix metalloproteinases (MMPs) and inhibited synovial proliferation by reducing ROS production, attenuating articular cartilage destruction in mice

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All animal experiments were approved by the Institutional Animal Care and Use Committee at the Institute of Biophysics, Chinese Academy of Science