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Expert Opin Pharmacother 2008

For Embase and Web of Science, we use the specific keywords and grammar rules of their respective platforms to adjust the conceptual framework, and add synonyms such as intestinal flora or fecal microbiota if necessary to improve sensitivity

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In a total of 20 studies (14 observational studies, 1 intervention study, and 5 rodent studies) for the systematic evaluation and analysis of VD and PD, it was reported in a meta-analysis of six observational studies reporting differences in VD levels that mean serum 25(OH)D levels in PD patients were lower than those in healthy controls, five studies in animal models of PD showed that supplemental VD intake in rodents significantly increased the concentrations of tyrosine hydroxylase, promoted the conversion of dopamine neurotransmitter, significantly decreased oxidative damage to the substantia nigra, and significantly increased dopamine levels and neuronal survival in the substantia nigra (87)

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AUTHOR CONTRIBUTIONS SU, CT, MT, GB, AMG, and PV performed and analyzed the experiments