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Accepted 4 September 2022

Also, the release of Ca 2+ from the mitochondria can be mediated by extracellular ATP bound to microglial purinergic receptors

Clin Physiol

Berberines anti-atherosclerotic efficacy potentially stems from its ability to reduce TMAO production, making it an excellent modulator for inhibiting atherosclerotic plaque development (Chen and Wang, 2021)