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In some embodiments, the compositions of the disclosure are applied into the ears as ear drops

However, their role in targeted gene or microenvironmental modulation remains limited

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Second, although selectivity over other mitochondrial enzymes has improved, off-target interactions with related sulfide oxidation pathways or broader redox networks remain a concern and need comprehensive screening

Providing acetate to LEC-depleted cells, as exogenous fuel for FAO, re-established a tubular mitochondrial network characteristic of respiring mitochondria (Fig