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17 Oxygen consumption during heavy exercise can increase up to 100 times normal resting levels, thus increasing the production of free radicals and resulting in oxidative stress

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In vitro experiments indicated that incubation of crude mitochondrial fraction from mouse brain with KCN (0.1, 1 and 2 mM) led to the damage of mtDNA and increased lipid peroxidation (0.1 and 1 mM KCN), which were not observed after co-treatment with melatonin (1 and 1.5 mM) (Fig

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Additionally, its well-developed nutrient acquisition system, through nutrient sensing pathways such as TOR and Ras-cAMP-PKA, regulates the secretion of iron carriers, carbon source metabolism conversion, and hyphal morphogenesis, efficiently scavenging key nutrients such as iron, nitrogen, and carbon from the host to provide core support for colonization, invasion, and virulence expression (Fleck et al., 2011)

PU-H71, a novel Hsp90 inhibitor, as a potential cancer-specific sensitizer to carbon-ion beam therapy