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An exploratory study of red raspberry ( Rubus idaeus L.) (poly)phenols/metabolites in human biological samples

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As inflammasomes induce pyroptosis and inflammation with potentially catastrophic results, they are tightly regulated through a two-step process of priming and activation ( 2.1.1 Priming of NLRP3 Resting cells typically exhibit low levels of NLRP3 mRNA, necessitating a priming step to enhance its expression (Franchi et al., 2009)

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Macrocyclic lactone Rapamycin, a macrocyclic lactone isolated from Streptomyces hygroscopicus , is known for its immunosuppressive and antimicrobial properties due to its ability to inhibit the mTOR pathway, thereby promoting autophagy [63]

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