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VRK2 facilitates ER-to-Golgi transport of SLC7A11 by promoting the phosphorylation of Sec24C and its interaction with SLC7A11, thereby enhancing GSH synthesis and rendering resistance to ferroptosis

In contrast, HCV reduced glutamate levels

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In MPTP-induced dopaminergic neurotoxicity in mice, two structural analogs of CDDO (TP-319 and TP-500), which are produced by the cyclization of squalene, have been shown to increase bloodbrain barrier permeability and provide protection against inflammation and oxidative stress [118]

Nrf2 regulates numerous target genes, all of which contain cis-acting enhancer sequences (5-TGACnnGC-3), a characteristic of ARE

Tian L, Qi J, Qian K, et al