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For the mother, obesity is a risk factor for GDM: the risk of GDM is 6.5 times higher in pregnancies complicated by obesity, hypertension, and preeclampsia than in normal-weight pregnancies

doi:10.1182/blood.2019002364 Baig MU, Bodle J

This orphan status has created a dichotomy in the scientific community: while empirical evidence from animal models and human clinical trials in the 1980s demonstrated significant therapeutic potential, particularly in addiction and stress management, the lack of a defined molecular pathway has stalled its development into a licensed pharmaceutical agent

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doi:10.1016/j.applanim.2019.02.013