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Knowledge about cerebrovascular involvement in neurological disorders is rapidly expanding, and increasing evidence indicates that defects in angiogenesis, and the bloodbrain boundary are causally related to the cognitive dysfunctions that may be found in the course of neurodegenerative disorders (Nicolakakis and Hamel 2011

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Ethnic background, particularly in individuals with darker skin tones, can influence the prominence of dark circles

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References 91, 97 and 105 describe the potential roles of TNF- and proteasome inhibition and in anthrax