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While it is unsurprising that many ALS symptoms are related to signs of copper deficiency, resulting in vascular, antioxidant system and mitochondrial oxidative respiration deficiencies, there are also signs of copper toxicity such as ROS generation and enhanced protein aggregation

Researchers investigating DSIPs interaction with stress-response pathways may also find it of interest alongside peptides like Selank, which has its own preclinical record in anxiety-related animal models, and Epitalon, which has been studied in aging and antioxidant contexts

With poorly controlled or severe disease, there is risk that extra-articular manifestations such as keratitis, pulmonary granulomas (rheumatoid nodules), pericarditis/pleuritis, small vessel vasculitis, and other non-specific extra-articular symptoms will develop

Proc Am Assoc Cancer Res 43:1099, 2002

Nature 417 , 299304 (2002)

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