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ADP/O: Ratio of ADP molecules phosphorylated to oxygen atoms reduced, reflecting phosphorylation efficiency

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These variations influence the balance between different network activities, leading to altered responses in the salience, visual, internal reward, and executive control networks, thereby highlighting the complex interplay between DA, reward network dysregulation, and the manifestation of depressive symptoms in CID patients (Gong et al., 2023)

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Some of these physiological adaptations can favor weight regain by increasing hunger and promoting energy storage