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Iron overload affects the progression of OA

The rats were assessed for significant alterations in renal markers, intestine and renal antioxidant levels, histopathology, cytokine levels (TNF-, IL-6, IL-10), and apoptosis marker expression range (caspase 3, 8, BCL-2)

Autonomic Nervous System Dysregulation When the sympathetic (fight or flight) branch is chronically overactive from stress, poor sleep, chronic pain, or metabolic dysfunction pressure stays elevated even at rest