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Consequently, changes in definite cytochrome P450 enzymes, as those previously evidenced in livers of patients with steatosis, but also in vivo models of steatosis (in experimental animals) and in vitro models of fat-overloaded cells, pose major impact on drug-induced hepatotoxicity (Gmez-Lechn et al., 2009), on the basis that CYP 3A4 is the main responsible for the metabolism of fentanyl (Figure 2) (Tateishi et al., 1996)

1, 1-bis (3indolyl)1(pmethoxyphenyl) methane activates Nur77independent proapoptotic responses in colon cancer cells, vol

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392 These results indicated that mitochondrial dysfunction, as well as the induced oxidative stress and inflammation aggravate sepsis and related complications

10.1016/j.jhazmat.2021.126490 210 WangN.ZhangS.LangfelderP.RamanathanL.GaoF.PlascenciaM.et al (2025)

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