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More specifically, vitamin B12 plays an important role in DNA synthesis, which itself is vital for cellular reproduction

BMC Pediatr

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NHS approach to B12 deficiency: NICE Clinical Knowledge Summaries recommend investigating B12 deficiency in patients presenting with macrocytic anaemia, unexplained neurological symptoms, or risk factors including pernicious anaemia, gastrectomy, malabsorption disorders, metformin use, proton pump inhibitors, or nitrous oxide exposure

For example: Proton pump inhibitors (PPIs) and H2 receptor antagonists, which are mainly used to reduce stomach acid, can affect the release of vitamin B12 from food and its absorption in the stomach