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For instance, recent studies have proposed a CRISPR-Cas9 based tool containing a deactivated Cas9 (dCas9) nuclease fused with a catalytic domain of DNMT and combined with co-expressed sgRNA, which achieves precise DNA methylation for specific targeted regions that are heritable across mitotic divisions in daughter cells [332, 333]

FIGURE 4 APC (adenomatous polyposis coli) encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway

Data availability The RNA-seq data used in this study were previously generated and published in our prior work 14

GLP-1 receptor activity GLP-1 signalling is associated with appetite reduction, delayed gastric emptying and glucose-dependent insulin support

Descriptive statistics were performed using Excel 2019