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Zhang Q, Li L, Li J, Wang H, Fang C, Yang X, He H

Mutations in KEAP1 or the augmentation of SQSTM1 (sequestosome 1)-mediated KEAP1 protein degradation can enhance the stability of NFE2L2 protein, enabling cancer cells to evade ferroptosis and acquire drug resistance [34]

Specifically, linking ONs - such as antisense oligonucleotides (ASOs) or short-interfering RNAs (siRNAs)to proteins or peptides can enhance properties like cell-specificity and cellular uptake 6 , which remain significant hurdles for many ON therapeutics

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Schmitz and colleagues [76] demonstrated that the IP3R is co-activated by IP3 and calcium ions and is potentiated by ATP