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Nat Rev Endocrinol (2011) 7:21931

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FASN emerged as the top candidate, with 10 cysteine sites showing increased oxidation levels, far exceeding other proteins, which had at most 2 sites (Figure 5G)

The pentose phosphate pathway (PPP) supports DNA replication and RNA production by regulating carbon flux between nucleic acid synthesis and lipogenesis, where key enzymes such as ribulose 5-phosphate isomerase (RPIA) and ribulose-5-phosphate-3-epimerase (RPE) are upregulated to maintain cell proliferation [271]