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Certain groups may need to take a B12 supplement for life

People with active or suspected cancer: Despite GHK-Cus anti-cancer potential, it theoretically could promote the formation of new blood vessels, which can feed tumors.3 9 14 People with anxiety or mood disorders: Similarly, although GHK-Cu has demonstrated an anxiolytic and anti-aggression effect in rats, the present research is too meager to support it as a viable treatment for anxiety or mood disorders

Curr Neurol Neurosci Rep 13:394

This is consistent with general pregnancy principles

This suggests that Nm serves as a critical regulatory brake, preventing excessive protein expression and ensuring precise control over protein synthesis, degradation, and nuclear export