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doi: 10.1371/journal.pone.0154090 245 GandyKAOZhangJNagarkattiPNagarkattiM

Genomic studies have uncovered several genetic markers underlying the pathology of pulmonary arterial hypertension and cardiomyopathies, which have been used to design polygenic risk score with prediction accuracies as high as 40% (46, 47, 51)

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10.1111/bph.14155 64 IadecolaC.AnratherJ

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Thus, it is inferred that lithium increases mitochondrial respiration, decreases the pro-apoptotic enzyme glycogen synthase kinase-3, and inhibits the expression of the pro-apoptotic genes Bax and p53