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Additionally, the adoption of this terminology may spur the development of therapies targeting metabolic pathways, offering patients more effective treatment options

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However, limitations exist in the form of in vivo instability, the reliance on carriers that are biocompatible and robust and limited sites of application (local and direct) (Park et al

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However, STEP 1 extension concluded that 1-year withdrawal of semaglutide results in regain of two-thirds of prior weight loss [97], highlighting that withdrawal of semaglutide results in weight regain which may be problematic in older adults who are already using polypharmacy approaches for comorbid disease