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In the cortex and hippocampus of patients with AD, NFTs accumulate in response to increased iron levels (43)

Nature 556 , 501504 (2018)

Role of diabetes in congestive heart failure: the Framingham study

NRF2 serves as a key therapeutic target for diabetic nephropathy via ferroptosis inhibition, exhibiting downregulated expression in diabetic models

Excess free iron can continuously generate ROS via the Fenton reaction, inducing lipid peroxidation, DNA damage, and protein denaturation, thereby contributing to structural and functional impairment of lung tissue (Turi et al., 2004)