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Description

Moreover, since Mn targets multiple genes and proteins, combination therapy strategies comprising of several relevant targets could be more beneficial for optimal treatment against Mn neurotoxicity

We previously produced the App NL-G-F/NL-G-F -KI ( App NL-G-F ) mouse strain using genomic DNA of introns 15 to 17 of mouse APP, which humanized the A sequence, and introduced KM670/671NL (Swedish), I716F (Iberian), and E693G (Arctic) mutations 41