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A cost-effectiveness analysis of DCD kidney transplantation

Conversely, excessive ROS accumulation leads to DNA damage, induction of p53 and Fas ligand (FasL), and ultimately T cell apoptosis ( Figure 1 ), which can be advantageous in terms of controlling autoimmunity ( Figure 1 Given this finite balance, it is not surprising that ROS are generated by multiple pathways following TCR activation and, in parallel, eliminated by multiple antioxidant systems

doi: 10.1136/ard-2022-222605 66 McGrathSGrimstadKThorarinsdottirKForslindKGlinatsiDLeu AgeliiMet al

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

Orlowski and Meister found that the ATP-driven reaction that combines glutamate and cysteine to generate -glutamyl cysteine (catalyzed by -glutamyl cysteine synthetase) (Figure 4A) can actually be subdivided into two distinct reaction steps (Figure 4B) (38,54)

2024;21(1):e00301