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Where deficiency is confirmed, treatment may include oral supplementation (for dietary insufficiency or mild malabsorption) or intramuscular hydroxocobalamin injections (for pernicious anaemia or severe malabsorption), as per NICE and British Society for Haematology guidelines

The available research has not demonstrated that B12 supplementation leads to significant reductions in body weight or body mass index (BMI) in people without deficiency

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J Agric Food Chem 58(8): 4712-4718

Further studies are required to determine to extent to which the neuroprotective effects of Nrf2 activation involve the prevention of ferroptosis

10.1038/s41419-025-07974-6 118 WangZ.LiY.WangC.LanJ.LiJ.LiuG.et al (2026)