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when 4-OHE2 is not cleared by COMT or SULT1A1, it oxidizes to quinones that GSTM1/GSTT1 must conjugate

Contributions of the GSH and Trx pathways in supporting RNR Although growth differences have not been reported between having only a GSH- or only a Trx-pathway (Holmgren, 1977

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Researchers have proposed a variety of factors which are related to the onset of cataractogenesis: enhanced permeability of the lens membrane, a decreased function of chaperone related to alpha crystalline, augmented non-enzymatic glycosylation, enhanced lipid peroxidation, and low capacity of antioxidant defence mechanism

Reduced ascorbate (AsA) was measured similarly, but with the addition of dithiothreitol (DTT) and 0.5% N-ethylmaleimide (NEM) to remove the excess of DTT

USA 86 , 68986902 (1989)