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20 Primarily, NADPH provides reducing equivalents for fatty acid synthase (FASN), the main rate-limiting enzyme, to synthesize fatty acids with acetyl-CoA serving as a primer and malonyl-CoA as a two-carbon donor, 21,22 and provides the needed electrons for ironsulfur (Fe/S) protein assembly that participate in non-essential amino acid biosynthesis and lipoic acid synthesis, tRNA modification, DNA replication and repair, and telomere maintenance

(2.1, 4.2, or 8.4 g/kg) for six weeks alleviated hepatic steatosis, oxidative stress, and inflammation in ALD rats via the gutliver axis by modulating the overall structure of the GM, such as maintaining the Firmicutes/Bacteroidetes ratio and reducing the relative abundance of harmful bacteria including Clostridium and Faecalibaculum, while activating the 15d-prostaglandin J2/Peroxisome proliferator-activated receptor (PPAR) and PPAR signaling pathways to lower serum levels of TNF-, IL-1, and IL-6, thereby improving lipid metabolism [121]

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doi: 10.1016/j.biomaterials.2011.08.001 242 RezvanfarMARezvanfarMAShahverdiARAhmadiABaeeriMMohammadiradAet al