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Common signs include: If these symptoms dont go away or get worse, see a doctor

A practical Evidence Tier system (so you can sanity-check any stack) Tier 1 Strong human evidence + regulatory clarity FDA-approved therapies with defined indications (e.g., tesamorelin for HIV-associated lipodystrophy

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This dual mechanism central anti-inflammatory via IRR and peripheral nociceptor inhibition via TRPV1 makes ARA-290 particularly relevant for neuropathic pain research models