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IGF-1R is a receptor tyrosine kinase that mediates the actions of IGF1, which binds with high affinity, whereas IGF2 and insulin bind to this receptor with low affinity [23]

This variation in range is due to factors such as gender, age and differences in body composition

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Schofield JH, Schafer ZT

Hygiene Hypothesis: Living in highly sanitized environments with reduced microbial exposure correlates with higher autoimmune disease rates, including Hashimotos thyroiditis

Additionally, NTFs-induced mitophagy exhibits the characteristic of selectively clearing mitochondria with high ROS production, a finding that provides new insights for targeted mitochondrial protection