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A: Dosage and schedule are determined by a physician based on individual needs

Nevertheless, the ever growing list of publications regarding this topic validates aaRSs as an extremely interesting target for drug design

Apurinic/Apyrimidinic (AP) sites in the brain, spinal cord, and brainstem of ALS patients are vulnerable to DNA lesions induced by free radicals and intermediates (Kim et al., 2020)

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However, topical formulations have also shown low bioavailability, mainly due to the low efficiency of transdermal administration and automatic photodegradation of EGCG [28]

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