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An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations

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In a LPS-challenged Caco-2 cells model, APS addition (100 or 200 g/mL) in cell culture remarkedly downregulated mRNA expression of TNF-, IL-1, and IL-8 in a dose manner (117)

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