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The liberation of free iron results in elevated iron levels, triggering the Fenton reaction and subsequent oxidative stress, ultimately leading to ferroptosis (Mancias et al., 2014)

Antioxidants (Basel) 12(3)

JAK, janus kinase

10.1161/01.CIR.103.16.2055 274

Gene aliases : G(h), hTG2, TG(C), TGC, tTG Gene ID : (Human) 7052 Gene symbol : TGM2 Protein Aliases : C polypeptide, protein-glutamine-gamma-glutamyltransferase, crosslinker, erythrocyte transglutaminase, G alpha h, G-ALPHA-h, GNAH, RP5-1054A22.2, TGase-H, Tissue type transglutaminase, Transglutaminase 2 C polypeptide, heart G alpha(h), hhG alpha(h), isopeptidase TGM2, protein G alpha(h), protein-glutamine deamidase TGM2, protein-glutamine dopaminyltransferase TGM2, protein-glutamine histaminyltransferase TGM2, protein-glutamine noradrenalinyltransferase TGM2, protein-glutamine serotonyltransferase TGM2, TGase C, TGase H, TGase II, TGase-2, tissue transglutaminase, transglutaminase C, transglutaminase H, transglutaminase II, tTgase, unnamed protein product UniProt ID (Human) P21980

Zhou et al., 2004