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In cultured cardiomyocytes, DOX concentrates in mitochondria, increasing mitochondrial iron deposition and ROS levels, and dexrazoxane has demonstrated efficacy in reversing DOX-induced cardiomyopathy by lowering mitochondrial iron levels

Paradoxically, while iron toxicity in PD is linked to dysfunctional iron metabolism, intragastric delivery of iron carbonyl boosts the biosynthesis of iron-sulfur clusters and elevates aconitase 1 activity, which is crucial for mitochondrial function and iron homeostasis, thereby preventing ferroptosis in vivo (188)

2004 January 286 (1):H39-46

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It lowers the oxidative stress that ages skin, evens out tone, and helps skin hold onto collagen, but it won't reverse aging on its own

16 , e9628 (2014)