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Schweiger, M

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It may also be part of therapy to treat Leber optic atrophy (an inherited optic neuropathy associated with a deficiency in vitamin B12).

This problem has now been overcome by using purified intrinsic factor which does not react with vitamin B12 analogs as the binder in the immune-enzymatic assays (Klee, 2000)

Even a single freeze-thaw event can reduce potency by 3050%, with no visual indication that degradation occurred

In the Phase 2 obesity trial it produced about 24% weight loss at 12 mg over 48 weeks, the most of any drug in the class, and it cut liver fat by 86% in the people who started with fatty liver. In the 80-week Phase 3 obesity trial of 2,300 adults with an average BMI of 40, 12 mg produced 28% weight loss and 9 mg reached 26%