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For example, PKA phosphorylates proteasomal subunits 38 and mTOR inhibition activates proteasomal activity 39

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Clinical manifestations frequently involve impairments in motor control and higher cognitive functions, including dementia, leading to a pronounced decline in the patients quality of life (5)

3.4 CBD and its derivatives exert synergistic antiproliferative effect with cisplatin Although chemical modifications improved the cytotoxicity of CBD in Caov-3 cells, these cannabinoids may not stand alone as anti-cancer drugs ( 19 and 21 can enhance the antiproliferative effect of cisplatin in Caov-3 cells