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18,19,20 In recent years, with the development of single-cell sequencing and multiomics, a variety of aging clocks 21 and aging panoramas 22,23 have emerged

Advise patients and caregivers: Hyperalgesia and Allodynia Inform patients and caregivers not to increase opioid dosage without first consulting a clinician

They function as chemical signals between cells, acting as hormones, neuromodulators, and growth factors [2]

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