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Dysregulation of the mitochondrial ACE2/MrgE/NO axis may have a significant effect on the neurodegenerative processes of dopaminergic neurons, where mitochondrial dysfunction and oxidative stress may have a substantial impact [76]

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Some of the strongest candidates involved in mitochondrial import of cytosolic GSH include the dicarboxylate transporter (DIC) and the 2-oxoglutarate transporter (OGC) which act as exchangers of Pi 2 (inorganic phosphorous) and 2-oxoglutarate (2-OG 2 7 ) for cytosolic GSH

Research indicates that iron overload can lead to increased ROS production, which in turn disrupts mitochondrial membrane potential and promotes cell death pathways such as ferroptosis

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