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Curcumin treatment significantly reduced mean BAI scores compared to placebo, suggesting curcumin as an anti-anxiety therapy for individuals with obesity and major depressive disorder (255)

Crucially, this signaling is bidirectional: central neuroendocrine outputs (e.g., via autonomic nerves and the HPA axis) reciprocally modulate gut physiologyaltering intestinal transit time, epithelial barrier permeability, and nutrient availabilitythereby reshaping the microbial metabolic environment and SCFA production capacity

Nuclear receptors as drug targets for metabolic disease

No difference was observed with the weighted UniFrac analysis (Fig

A recent randomized, double-blind clinical trial tested whether targeted brain stimulation could alter that course

Brain 134 , 19141924 (2011)