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At present, although some studies have suggested the inhibitory effect of ROS on NK cell activity in the TME, the study of ROS in NK cells in the glioma TME is still limited

Additionally, changes in the GM composition have been linked to oxidative stress, activation of the complement system, inflammation, and altered choroidal hemodynamics

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[DOI] [PubMed] 149.Aisen P.S., Gauthier S., Ferris S.H., Saumier D., Haine D., Garceau D., Duong A., Suhy J., Oh J., Lau W.C., Sampalis J

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These alterations may be related to mitochondrial malfunction brought on by DOX administration