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10.1016/j.genhosppsych.2025.03.012 252 LatifiS.TamayolA.HabibeyR.SabzevariR.KahnC.GenyD.et al

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ABCG2 is upregulated in the extracellular vesicle (EV) membranes of neighboring breast cancer cells, and actively pumps chemotherapeutic drugs from the cytosol into the vesicle lumen, resulting in an MDR phenotype (Goler-Baron and Assaraf, 2011)

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Once internal standard concentrations were obtained, the peak areas of the unlabelled metabolites in the samples of culture medium were compared with the peak area of the quantified internal standard to determine the metabolite concentration in the sample