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The term mTORopathy is used in the context of neurological diseases, especially epileptic encephalopathies and cortical malformations such as tuberous sclerosis due to mutations in TSC1 or TSC2

6 In the brain, that antioxidant support matters for the neural pathways involved in focus, recall, and mental energy

Hesperidin: A review on extraction methods, stability and biological activities

However, this inhibition of ferroptosis by mTOR can be overcome through the use of ferroptosis inducers such as salinomycin (Sal), which sequesters iron into lysosomes, creating oxidative stress and lipid peroxidation that triggers ferroptotic cell death

CAF-derived exosomes have been shown to contain amino acids, lipids and TCA intermediates that inhibit mitochondrial oxidative phosphorylation, thereby increasing glutamine-dependent reductive carboxylation and promote glycolysis in tumor cells [149]