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Additionally, when applied topically, linoleic acid exhibits comedolytic properties and has the potential to decrease the size of microcomedones [189]

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12-plex RNA-ISH exhibited sufficient sensitivity and specificity for some high-expressing cell lineage markers, but struggled to adequately measure genes expressed at lower levels, including ITGA4, ITGB7 , MADCAM1 , and FLT3 (Supplementary Fig 13a, b, Supplementary Table 3)

This complex assessment could help to cluster patients into subgroups that can be better explained by specific biological dysfunctions