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Quinolones, including chloroquine and amodiaquine, act by inhibiting the conversion of free heme to hemozoin within the infected erythrocyte, effectively increasing oxidative stress for Plasmodium parasites ( P

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Interestingly, the combination of 1 or 100 M SAC + 500 M TMZ maintained GSH levels below the control, and even below SAC alone, both in RG2 (5A) and C6 (5B) cells, and these changes were statistically different from the control group ( p 0.05) and the TMZ group ( p 0.01)