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Immune system: Leptin also is important in the immune response, and immune system cells, such as macrophages, have leptin receptors

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These studies can be useful for understanding how receptor activation translates into signaling persistence and downstream program selection in controlled model systems

[DOI] [PubMed] [Google Scholar] 63.Tomofuji T, Sanbe T, Ekuni D, Azuma T, Irie K, Maruyama T, et al

Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Engen et al., 2020) (Figure 10)

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