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In one study, the clearance of free valproate was decreased by 50% in 7 patients with cirrhosis and by 16% in 4 patients with acute hepatitis, compared with 6 healthy subjects

Sensitivity analysis A sensitivity analysis was conducted by excluding the study by Ikechukwu et al

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NOS1 is highly expressed in the hippocampus, and selective inhibition of NOS1 can block NO production and inhibit long-term potentiation, affecting cognitive function, particularly working memory [80,81,82]