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Certain athlete populations may be at an increased risk and may need to supplement their diet after food intake analysis and regular testing

In the presence of neurological symptoms, following daily treatment, injections up to weekly or biweekly are indicated for six months before initiating monthly IM injections

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A randomized, placebo-controlled trial in 559 elderly individuals with low serum levels of folate and vitamin B 12 and at increased risk of fracture evaluated the combined supplementation of very high doses of folic acid (5 mg/day) and vitamin B 12 (1.5 mg/day)

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